CREBBP Antibody
Produktgrößen
100ul
£359,00
OASG01131-100UL
Über dieses Produkt
- SKU:
- OASG01131
- Zusätzliche Namen:
- CBP; RSTS; KAT3A; MKHK1; RSTS1
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene is ubiquitously expressed and is involved in the transcriptional coactivation of many different transcription factors. First isolated as a nuclear protein that binds to cAMP-response element binding protein (CREB); this gene is now known to play critical roles in embryonic development; growth control; and homeostasis by coupling chromatin remodeling to transcription factor recognition. The protein encoded by this gene has intrinsic histone acetyltransferase activity and also acts as a scaffold to stabilize additional protein interactions with the transcription complex. This protein acetylates both histone and non-histone proteins. This protein shares regions of very high sequence similarity with protein p300 in its bromodomain; cysteine-histidine-rich regions; and histone acetyltransferase domain. Mutations in this gene cause Rubinstein-Taybi syndrome (RTS). Chromosomal translocations involving this gene have been associated with acute myeloid leukemia. Alternative splicing results in multiple transcript variants encoding different isoforms.
- Gendetails:
- CREB binding protein
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human CBP around the acetylation site of K1535. Location: 1480-1550aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 265 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php