CBL Antibody
Produktgrößen
100ul
£359,00
OASG01125-100UL
Über dieses Produkt
- SKU:
- OASG01125
- Zusätzliche Namen:
- CBL2; NSLL; C-CBL; RNF55; FRA11B
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene is a proto-oncogene that encodes a RING finger E3 ubiquitin ligase. The encoded protein is one of the enzymes required for targeting substrates for degradation by the proteasome. This protein mediates the transfer of ubiquitin from ubiquitin conjugating enzymes (E2) to specific substrates. This protein also contains an N-terminal phosphotyrosine binding domain that allows it to interact with numerous tyrosine-phosphorylated substrates and target them for proteasome degradation. As such it functions as a negative regulator of many signal transduction pathways. This gene has been found to be mutated or translocated in many cancers including acute myeloid leukaemia. Mutations in this gene are also the cause of Noonan syndrome-like disorder.
- Gendetails:
- Cbl proto-oncogene; E3 ubiquitin protein ligase
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Cbl around the phosphorylation site of Y774. Location: 710-790aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 100 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php