CTNNB1 Antibody
Produktgrößen
100ul
£359,00
OASG01072-100UL
Über dieses Produkt
- SKU:
- OASG01072
- Zusätzliche Namen:
- EVR7; CTNNB; MRD19; NEDSDV; armadillo
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt; forms a complex with AXIN1; AXIN2; APC; CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand; CTNNB1 is not ubiquitinated and accumulates in the nucleus; where it acts as a coactivator for transcription factors of the TCF/LEF family; leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion; as component of an E-cadherin:catenin adhesion complex. Acts as a negative regulator of centrosome cohesion. Involved in the CDK2/PTPN6/CTNNB1/CEACAM1 pathway of insulin internalization. Blocks anoikis of malignant kidney and intestinal epithelial cells and promotes their anchorage-independent growth by down-regulating DAPK2. Disrupts PML function and PML-NB formation by inhibiting RANBP2-mediated sumoylation of PML . Promotes neurogenesis by maintaining sympathetic neuroblasts within the cell cycle.
- Gendetails:
- catenin (cadherin-associated protein); beta 1; 88kDa
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Catenin-Beta around the phosphorylation site of Y654. Location: 590-670aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 75 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20°C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php