CASP8 Antibody
Produktgrößen
100ul
£359,00
OASG01047-100UL
Über dieses Produkt
- SKU:
- OASG01047
- Zusätzliche Namen:
- CAP4; MACH; MCH5; FLICE; ALPS2B; Casp-8
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene encodes a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes composed of a prodomain; a large protease subunit; and a small protease subunit. Activation of caspases requires proteolytic processing at conserved internal aspartic residues to generate a heterodimeric enzyme consisting of the large and small subunits. This protein is involved in the programmed cell death induced by Fas and various apoptotic stimuli. The N-terminal FADD-like death effector domain of this protein suggests that it may interact with Fas-interacting protein FADD. This protein was detected in the insoluble fraction of the affected brain region from Huntington disease patients but not in those from normal controls; which implicated the role in neurodegenerative diseases. Many alternatively spliced transcript variants encoding different isoforms have been described; although not all variants have had their full-length sequences determined.
- Gendetails:
- caspase 8; apoptosis-related cysteine peptidase
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Caspase-8 around the phosphorylation site of S347. Location: 290-370aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 55 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php