CASP3 Antibody
Produktgrößen
100ul
£359,00
OASG01029-100UL
Über dieses Produkt
- SKU:
- OASG01029
- Zusätzliche Namen:
- CPP32; SCA-1; CPP32B
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop-helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6; -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. / Strict requirement for an Asp residue at positions P1 and P4. It has a preferred cleavage sequence of Asp-Xaa-Xaa-Asp-|- with a hydrophobic amino-acid residue at P2 and a hydrophilic amino-acid residue at P3; although Val or Ala are also accepted at this position. / Inhibited by isatin sulfonamides.
- Gendetails:
- caspase 3; apoptosis-related cysteine peptidase
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the Internal region of human Caspase-3 p17. Location: 100-180aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 35/17 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php