BRCA1 Antibody
Produktgrößen
100ul
£359,00
OASG00823-100UL
Über dieses Produkt
- SKU:
- OASG00823
- Zusätzliche Namen:
- IRIS; PSCP; BRCAI; BRCC1; FANCS; PNCA4; RNF53; BROVCA1; PPP1R53
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene encodes a nuclear phosphoprotein that plays a role in maintaining genomic stability; and it also acts as a tumor suppressor. The encoded protein combines with other tumor suppressors; DNA damage sensors; and signal transducers to form a large multi-subunit protein complex known as the BRCA1-associated genome surveillance complex (BASC). This gene product associates with RNA polymerase II; and through the C-terminal domain; also interacts with histone deacetylase complexes. This protein thus plays a role in transcription; DNA repair of double-stranded breaks; and recombination. Mutations in this gene are responsible for approximately 40% of inherited breast cancers and more than 80% of inherited breast and ovarian cancers. Alternative splicing plays a role in modulating the subcellular localization and physiological function of this gene. Many alternatively spliced transcript variants; some of which are disease-associated mutations; have been described for this gene; but the full-length natures of only some of these variants has been described. A related pseudogene; which is also located on chromosome 17; has been identified.
- Gendetails:
- breast cancer 1; early onset
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human BRCA1 around the non-phosphorylation site of S1423. Location: 1360-1440aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 180 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php