AIFM1 Antibody - N-terminal region
Produktgrößen
100ul
£359,00
OASG00246-100UL
Über dieses Produkt
- SKU:
- OASG00246
- Zusätzliche Namen:
- AIF; AUNX1; CMT2D; CMTX4; COWCK; DFNX5; NADMR; NAMSD; PDCD8; COXPD6; SEMDHL
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene encodes a flavoprotein essential for nuclear disassembly in apoptotic cells; and it is found in the mitochondrial intermembrane space in healthy cells. Induction of apoptosis results in the translocation of this protein to the nucleus where it affects chromosome condensation and fragmentation. In addition; this gene product induces mitochondria to release the apoptogenic proteins cytochrome c and caspase-9. Mutations in this gene cause combined oxidative phosphorylation deficiency 6 (COXPD6); a severe mitochondrial encephalomyopathy; as well as Cowchock syndrome; also known as X-linked recessive Charcot-Marie-Tooth disease-4 (CMTX-4); a disorder resulting in neuropathy; and axonal and motor-sensory defects with deafness and mental retardation. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 10.
- Gendetails:
- apoptosis-inducing factor; mitochondrion-associated; 1
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from the N-terminal region of human AIF-M1. Location: 30-110aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 67 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php