ABL1 Antibody
Produktgrößen
100ul
£359,00
OASG00123-100UL
Über dieses Produkt
- SKU:
- OASG00123
- Zusätzliche Namen:
- ABL; JTK7; p150; c-ABL; v-abl; CHDSKM; c-ABL1; BCR-ABL; bcr/abl
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes; including cell division; adhesion; differentiation; and response to stress. The activity of the protein is negatively regulated by its SH3 domain; whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation; suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias; most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants; which contain alternative first exons that are spliced to the remaining common exons.
- Gendetails:
- ABL proto-oncogene 1; non-receptor tyrosine kinase
- Host:
- Rabbit
- Immunogen:
- Synthesized peptide derived from human Abl1 around the phosphorylation site of Y204. Location: 130-210aa.
- Isotyp:
- IgG
- Molekulargewicht:
- 123 kDa
- Aufreinigung:
- The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C. Avoid repeated freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php