EXOSC1 Antibody
Produktgrößen
100 µg
£849,00
OARA02228-100UG
Über dieses Produkt
- SKU:
- OARA02228
- Zusätzliche Namen:
- 3'-5' exoribonuclease CSL4 homolog;CGI-108;CSL4;Csl4p;exosomal core protein CSL4;exosome complex component CSL4;Exosome component 1;homolog of yeast exosomal core protein CSL4;p13;PCH1F;SKI4;Ski4p.
- translate.label.attr.clone:
- BM3
- Klonalität:
- Monoclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus; the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA; snRNA and snoRNA; in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts; such as antisense RNA species and promoter-upstream transcripts (PROMPTs); and of mRNAs with processing defects; thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm; the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions; and in RNA surveillance pathways; preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis; and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8.
- Gendetails:
- exosome component 1
- Host:
- Mouse
- Immunogen:
- A BALB/c mouse was immunized with nuclei from Pokeweed mitogen stimulated human peripheral blood lymphocytes.
- Proteindetails:
- Exosome complex component CSL4
- Versandbedingungen:
- Dry Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C|-20Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php