CaM Kinase II Antibody
Produktgrößen
100 ul
£587,00
OAPC00145-100UL
Über dieses Produkt
- SKU:
- OAPC00145
- Zusätzliche Namen:
- PKCCD; PK2CDD
- Klonalität:
- Polyclonal
- Weitere Details:
- Ca2+/calmodulin-dependent protein kinase II (CaM Kinase II) is a multi-functional calcium and calmodulin-dependent protein kinase that mediates cellular responses to a wide variety of intercellular signals (Kennedy; 1998; Schulman and Hanson; 1993). CaM Kinase II has been shown to regulate diverse cellular functions including synaptic plasticity; neurotransmitter synthesis and release; gene expression; ion channel function; carbohydrate metabolism; cytoskeletal function; and Ca2+-homeostasis (Gleason et al.; 2003; Soderling; 2000; Hudmon and Schulman; 2002). Phosphorylation of Thr286 on the kinase produces an autonomously active form of CaM Kinase II (Meng et al.; 2003; Picciotto et al.; 1993). Autophosphorylation of Thr305 inhibits the activity CaM Kinase II. Phosphorylation at this site appears to reduce the association of CaM Kinase II with the PSD and reduce LTP and learning (Elgersma et al.; 2002).
- Host:
- Rabbit
- Immunogen:
- Phosphopeptide corresponding to amino acid residues surrounding the phospho-Thr286 found in rat brain CaM Kinase II.
- Molekulargewicht:
- ~50kDa Alpha & ~60kDa Beta
- Proteindetails:
- Calcium/calmodulin-dependent protein kinase type II subunit alpha
- Aufreinigung:
- Prepared from rabbit serum by affinity purification via sequential chromatography on phospho- and dephosphopeptide affinity columns.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For long term storage -20C is recommended. Stable at -20C for at least 1 year.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php