Anti-NMDA Receptor; NR1 Subunit
Produktgrößen
15 ug
£587,00
OAPC00043-15UG
Über dieses Produkt
- SKU:
- OAPC00043
- Zusätzliche Namen:
- NR1; GluN1; NMDAR1
- translate.label.attr.clone:
- R1JHL
- Klonalität:
- Monoclonal
- Weitere Details:
- The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and alpha -amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory; neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimer's; epilepsy and ischemic neuronal cell death (Grosshans et al.; 2002; Wenthold et al.; 2003; Carroll and Zukin; 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al.; 1989; Alvestad et al.; 2003; Snell et al.; 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al.; 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1-subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.
- Host:
- Mouse
- Immunogen:
- Fusion protein containing amino acids 1-564 of the NR1 subunit of rat NMDA receptor.
- Isotyp:
- Not determined
- Molekulargewicht:
- ~120kDa
- Proteindetails:
- Glutamate receptor ionotropic; NMDA 1
- Aufreinigung:
- Culture supernatant
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For long term storage -20C is recommended. Stable at -20C for at least 1 year.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php