Anti-Alpha-Internexin
Produktgrößen
100 ul
£543,00
OAPC00002-100UL
Über dieses Produkt
- SKU:
- OAPC00002
- Zusätzliche Namen:
- Nf66; Inexa; Intlaa; alpha-Inx
- translate.label.attr.clone:
- 1D2
- Klonalität:
- Monoclonal
- Weitere Details:
- Alpha-internexin is a Class IV intermediate filament originally discovered as it co-purifies with other neurofilament subunits (1). Alpha-internexin is related to but distinct from the better known neurofilament triplet proteins; NF-L; NF-M and NF-H; having similar protein sequence motifs and a similar intron organization. It is expressed only in neurons and in large amounts early in neuronal development; but is down-regulated in many neurons as development proceeds. Many classes of mature neurons contain alpha-internexin in addition to NF-L; NF-M and NF-H. In some mature neurons alpha-internexin is the only neurofilament subunit expressed. Antibodies to alpha-internexin are therefore unique probes to study and classify neuronal types and follow their processes in sections and in tissue culture. In addition; recent studies show a marked up-regulation of alpha-internexin during neuronal regeneration (2). The use of antibodies to this protein in the study of brain tumors has not been examined to date; but is likely to be of interest. Recently Cairns et al. used this antibody to show that alpha-internexin is an abundant component of the inclusions of neurofilament inclusion body disease (NFID); a serious human neurodegenerative disorder (3;4). The antibody was also used to confirm the presence of circulating auto-antibodies to alpha-internexin in the sera of some patients with endocrine autoimmunity; as well as in some normal individuals (5).
- Host:
- Mouse
- Immunogen:
- Recombinant rat alpha-internexin expressed in and purified from E. coli.
- Isotyp:
- IgG<sup>1</sup>
- Molekulargewicht:
- ~66kDa
- Proteindetails:
- Alpha-internexin
- Aufreinigung:
- Total IgG fraction
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at -20C in undiluted aliquots; stable for at least 1 year. Avoid freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php