ARID1A Antibody - N-terminal
Produktgrößen
0.1 mg
£652,00
OAPB02022-0.1MG
Über dieses Produkt
- SKU:
- OAPB02022
- Zusätzliche Namen:
- ARID domain-containing protein 1A;AT rich interactive domain 1A (SWI-like);AT-rich interactive domain-containing protein 1A;B120;BAF250;BAF250a;BM029;brain protein 120;BRG1-associated factor 250;BRG1-associated factor 250a;C1orf4;chromatin remodeling factor p250;CSS2;ELD;hELD;hOSA1;MRD14;osa homolog 1;OSA1;OSA1 nuclear protein;P270;SMARCF1;SWI/SNF complex protein p270;SWI/SNF-related; matrix-associated; actin-dependent regulator of chromatin subfamily F member 1;SWI-like protein.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities; changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Binds DNA non-specifically. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons; npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A; are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth (By similarity).
- Gendetails:
- AT-rich interaction domain 1A
- Host:
- Rabbit
- Immunogen:
- ARID1A antibody was raised against an 18 amino acid peptide near the amino terminus of human ARID1A. The immunogen is located within amino acids 580 - 630 of ARID1A.
- Isotyp:
- IgG
- Molekulargewicht:
- Predicted: 133; 227; 251 kDa Observed: 130; 260 kDa
- Proteindetails:
- AT-rich interactive domain-containing protein 1A|AT-rich interactive domain-containing protein 1A isoform a [Homo sapiens]
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Store at 4°C for three months and -20°C for 1 year
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php