DOCK8 Antibody - C-terminal
Produktgrößen
0.1 mg
£652,00
OAPB01910-0.1MG
Über dieses Produkt
- SKU:
- OAPB01910
- Zusätzliche Namen:
- 1200017A24Rik;dedicator of cytokinesis protein 8;epididymis luminal protein 205;HEL-205;MRD2;ZIR8.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Guanine nucleotide exchange factor (GEF) which specifically activates small GTPase CDC42 by exchanging bound GDP for free GTP (PubMed:28028151; PubMed:22461490). During immune responses; required for interstitial dendritic cell (DC) migration by locally activating CDC42 at the leading edge membrane of DC (By similarity). Required for CD4(+) T-cell migration in response to chemokine stimulation by promoting CDC42 activation at T cell leading edge membrane (PubMed:28028151). Is involved in NK cell cytotoxicity by controlling polarization of microtubule-organizing center (MTOC); and possibly regulating CCDC88B-mediated lytic granule transport to MTOC during cell killing (PubMed:25762780).
- Gendetails:
- dedicator of cytokinesis 8
- Host:
- Rabbit
- Immunogen:
- DOCK8 antibody was raised against a 17 amino acid peptide near the carboxy terminus of human DOCK8. The immunogen is located within the last 50 amino acids of DOCK8.
- Isotyp:
- IgG
- Molekulargewicht:
- Predicted: 166; 220; 231 kDa Observed: 220; 230 kDa
- Proteindetails:
- Dedicator of cytokinesis protein 8|dedicator of cytokinesis protein 8 isoform 1 [Homo sapiens]
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php