DNM1L Antibody - N-terminal
Produktgrößen
0.1 mg
£652,00
OAPB01835-0.1MG
Über dieses Produkt
- SKU:
- OAPB01835
- Zusätzliche Namen:
- DLP1;Dnm1p/Vps1p-like protein;DRP1;DVLP;DYMPLE;dynamin family member proline-rich carboxyl-terminal domain less;dynamin-1-like protein;Dynamin-like protein;dynamin-like protein 4;dynamin-like protein IV;dynamin-related protein 1;EMPF;EMPF1;HDYNIV;OPA5.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Functions in mitochondrial and peroxisomal division. Mediates membrane fission through oligomerization into membrane-associated tubular structures that wrap around the scission site to constrict and sever the mitochondrial membrane through a GTP hydrolysis-dependent mechanism. Through its function in mitochondrial division; ensures the survival of at least some types of postmitotic neurons; including Purkinje cells; by suppressing oxidative damage. Required for normal brain development; including that of cerebellum. Facilitates developmentally regulated apoptosis during neural tube formation. Required for a normal rate of cytochrome c release and caspase activation during apoptosis; this requirement may depend upon the cell type and the physiological apoptotic cues. Plays an important role in mitochondrial fission during mitosis (PubMed:26992161). Required for formation of endocytic vesicles. Proposed to regulate synaptic vesicle membrane dynamics through association with BCL2L1 isoform Bcl-X(L) which stimulates its GTPase activity in synaptic vesicles; the function may require its recruitment by MFF to clathrin-containing vesicles. Required for programmed necrosis execution.
- Gendetails:
- dynamin 1 like
- Host:
- Rabbit
- Immunogen:
- DNM1L antibody was raised against a 19 amino acid peptide near the center of human DNM1L. The immunogen is located within amino acids 530 - 580 of DNM1L.
- Isotyp:
- IgG
- Molekulargewicht:
- Predicted: 81 kDa Observed: 80 kDa
- Proteindetails:
- Dynamin-1-like protein|dynamin-1-like protein isoform 1 [Homo sapiens]
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php