FHIT Antibody - C-terminal
Produktgrößen
0.1 mg
£652,00
OAPB01791-0.1MG
Über dieses Produkt
- SKU:
- OAPB01791
- Zusätzliche Namen:
- AP3A hydrolase;AP3Aase;bis(5'-adenosyl)-triphosphatase;diadenosine 5';5'''-P1;P3-triphosphate hydrolase;dinucleosidetriphosphatase;FRA3B;Fragile histidine triad protein.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Cleaves P(1)-P(3)-bis(5'-adenosyl) triphosphate (Ap3A) to yield AMP and ADP. Can also hydrolyze P(1)-P(4)-bis(5'-adenosyl) tetraphosphate (Ap4A); but has extremely low activity with ATP. Modulates transcriptional activation by CTNNB1 and thereby contributes to regulate the expression of genes essential for cell proliferation and survival; such as CCND1 and BIRC5. Plays a role in the induction of apoptosis via SRC and AKT1 signaling pathways. Inhibits MDM2-mediated proteasomal degradation of p53/TP53 and thereby plays a role in p53/TP53-mediated apoptosis. Induction of apoptosis depends on the ability of FHIT to bind P(1)-P(3)-bis(5'-adenosyl) triphosphate or related compounds; but does not require its catalytic activity; it may in part come from the mitochondrial form; which sensitizes the low-affinity Ca(2+) transporters; enhancing mitochondrial calcium uptake. Functions as tumor suppressor.
- Gendetails:
- fragile histidine triad diadenosine triphosphatase
- Host:
- Rabbit
- Immunogen:
- FHIT antibody was raised against an 18 amino acid peptide near the carboxy terminus of human FHIT. The immunogen is located within the last 50 amino acids of FHIT .
- Isotyp:
- IgG
- Molekulargewicht:
- Predicted: 16 kDa Observed: 15kDa
- Proteindetails:
- Bis(5'-adenosyl)-triphosphatase|bis(5'-adenosyl)-triphosphatase isoform 1 [Homo sapiens]
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php