ESRRB Antibody - C-terminal
Produktgrößen
0.1 mg
£652,00
OAPB01574-0.1MG
Über dieses Produkt
- SKU:
- OAPB01574
- Zusätzliche Namen:
- DFNB35;ERR beta-2;ERR2;ERRb;ERRbeta2;ESRL2;estrogen receptor-like 2;estrogen-related nuclear receptor beta;Estrogen-related receptor beta;NR3B2;nuclear receptor ERRB2;nuclear receptor subfamily 3 group B member 2;orphan nuclear receptor;steroid hormone receptor ERR2.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Isoform 3: Transcription factor that binds a canonical ESRRB recognition (ERRE) sequence 5'TCAAGGTCA-3' localized on promoter and enhancer of targets genes regulating their expression or their transcription activity (PubMed:17920186; PubMed:19755138). Plays a role; in a LIF-independent manner; in maintainance of self-renewal and pluripotency of embryonic and trophoblast stem cells through different signaling pathways including FGF signaling pathway and Wnt signaling pathways. Upon FGF signaling pathway activation; interacts with KDM1A by directly binding to enhancer site of ELF5 and EOMES and activating their transcription leading to self-renewal of trophoblast stem cells. Also regulates expression of multiple rod-specific genes and is required for survival of this cell type (By similarity). Plays a role as transcription factor activator of GATA6; NR0B1; POU5F1 and PERM1 (PubMed:23836911). Plays a role as transcription factor repressor of NFE2L2 transcriptional activity and ESR1 transcriptional activity (PubMed:17920186; PubMed:19755138). During mitosis remains bound to a subset of interphase target genes; including pluripotency regulators; through the canonical ESRRB recognition (ERRE) sequence; leading to their transcriptional activation in early G1 phase. Can coassemble on structured DNA elements with other transcription factors like SOX2; POU5F1; KDM1A and NCOA3 to trigger ESRRB-dependent gene activation. This mechanism; in the case of SOX2 corecruitment prevents the embryonic stem cells (ESCs) to epiblast stem cells (EpiSC) transition through positive regulation of NR0B1 that inhibits the EpiSC transcriptional program. Also plays a role inner ear development by controlling expression of ion channels and transporters and in early placentation (By similarity).
- Gendetails:
- estrogen related receptor beta
- Host:
- Rabbit
- Immunogen:
- ESRRB antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human ESRRB. The immunogen is located within amino acids 360 - 410 of ESRRB.
- Isotyp:
- IgG
- Proteindetails:
- Steroid hormone receptor ERR2|steroid hormone receptor ERR2 [Homo sapiens]
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 2-8C up to 1 week. For long term storage; store at -20C in small aliquots to prevent freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php