ERBB2 Antibody
Produktgrößen
0.1 mg
£652,00
OAPB00881-0.1MG
Über dieses Produkt
- SKU:
- OAPB00881
- Zusätzliche Namen:
- CD340;c-erb B2/neu protein;HER2;HER-2;HER-2/neu;herstatin;human epidermal growth factor receptor 2;metastatic lymph node gene 19 protein;MLN 19;NEU;neuro/glioblastoma derived oncogene homolog;neuroblastoma/glioblastoma derived oncogene homolog;NGL;p185erbB2;proto-oncogene c-ErbB-2;proto-oncogene Neu;receptor tyrosine-protein kinase erbB-2;TKR1;tyrosine kinase-type cell surface receptor HER2;v-erb-b2 avian erythroblastic leukemia viral oncogene homolog 2;v-erb-b2 avian erythroblastic leukemia viral oncoprotein 2;v-erb-b2 erythroblastic leukemia viral oncogene homolog 2; neuro/glioblastoma derived oncogene homolog;VSCN2.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Protein tyrosine kinase that is part of several cell surface receptor complexes; but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex; although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation; the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2; allowing its association with the cell membrane. In turn; membrane-bound APC allows the localization of MACF1 to the cell membrane; which is required for microtubule capture and stabilization.
- Gendetails:
- erb-b2 receptor tyrosine kinase 2
- Immunogen:
- erbB-2 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human erbB-2. The immunogen is located within the last 50 amino acids of erbB-2.
- Isotyp:
- IgY
- Proteindetails:
- Receptor tyrosine-protein kinase erbB-2|receptor tyrosine-protein kinase erbB-2 isoform a precursor [Homo sapiens]
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- erbB-2 antibody can be stored at 4C for three months and -20C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php