BRSK1 Antibody
Produktgrößen
0.1 mg
£652,00
OAPB00508-0.1MG
Über dieses Produkt
- SKU:
- OAPB00508
- Zusätzliche Namen:
- BR serine/threonine-protein kinase 1;brain-selective kinase 1;brain-specific serine/threonine-protein kinase 1;hSAD1;protein kinase SAD1A;SAD1 homolog;SAD1 kinase;serine/threonine-protein kinase BRSK1;serine/threonine-protein kinase SAD-B;synapses of Amphids Defective homolog 1.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Serine/threonine-protein kinase that plays a key role in polarization of neurons and centrosome duplication. Phosphorylates CDC25B; CDC25C; MAPT/TAU; RIMS1; TUBG1; TUBG2 and WEE1. Following phosphorylation and activation by STK11/LKB1; acts as a key regulator of polarization of cortical neurons; probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in post-mitotic neurons; leading to down-regulate WEE1 activity in polarized neurons. In neurons; localizes to synaptic vesicles and plays a role in neurotransmitter release; possibly by phosphorylating RIMS1. Also acts as a positive regulator of centrosome duplication by mediating phosphorylation of gamma-tubulin (TUBG1 and TUBG2) at 'Ser-131'; leading to translocation of gamma-tubulin and its associated proteins to the centrosome. Involved in the UV-induced DNA damage checkpoint response; probably by inhibiting CDK1 activity through phosphorylation and activation of WEE1; and inhibition of CDC25B and CDC25C.
- Gendetails:
- BR serine/threonine kinase 1
- Host:
- Rabbit
- Immunogen:
- BRSK1 antibody was raised against a 28 amino acid synthetic peptide from near the carboxy terminus of human BRSK1. The immunogen is located within amino acids 720 - 770 of BRSK1.
- Proteindetails:
- Serine/threonine-protein kinase BRSK1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- BRSK1 antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php