Cbl Antibody
Produktgrößen
0.1 mg
£652,00
OAPB00462-0.1MG
Über dieses Produkt
- SKU:
- OAPB00462
- Zusätzliche Namen:
- Cas-Br-M (murine) ecotropic retroviral transforming sequence;casitas B-lineage lymphoma proto-oncogene;Cbl proto-oncogene; E3 ubiquitin protein ligase;CBL2;C-CBL;E3 ubiquitin-protein ligase CBL;FRA11B;fragile site; folic acid type; rare; fra(11)(q23.3);NSLL;oncogene CBL2;proto-oncogene c-Cbl;RING finger protein 55;RING-type E3 ubiquitin transferase CBL;RNF55;signal transduction protein CBL.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase; which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes; and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases; including KIT; FLT1; FGFR1; FGFR2; PDGFRA; PDGFRB; EGFR; CSF1R; EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK; SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be functionally coupled with the E2 ubiquitin-protein ligase UB2D3.
- Gendetails:
- Cbl proto-oncogene
- Host:
- Rabbit
- Immunogen:
- Cbl antibody was raised against a 14 amino acid synthetic peptide from near the carboxy terminus of human cbl. The immunogen is located within amino acids 810 - 860 of Cbl.
- Proteindetails:
- E3 ubiquitin-protein ligase CBL
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Cbl antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php