DDX58 Antibody
Produktgrößen
0.1 mg
£652,00
OAPB00457-0.1MG
Über dieses Produkt
- SKU:
- OAPB00457
- Zusätzliche Namen:
- antiviral innate immune response receptor RIG-I;DEAD (Asp-Glu-Ala-Asp) box polypeptide 58;DEAD box protein 58;DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide;probable ATP-dependent RNA helicase DDX58;retinoic acid-inducible gene 1 protein;retinoic acid-inducible gene I protein;RIG1;RIGI;RIG-I;RIG-I-like receptor 1;RLR-1;RNA helicase RIG-I;SGMRT2.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Innate immune receptor which acts as a cytoplasmic sensor of viral nucleic acids and plays a major role in sensing viral infection and in the activation of a cascade of antiviral responses including the induction of type I interferons and proinflammatory cytokines. Its ligands include: 5'-triphosphorylated ssRNA and dsRNA and short dsRNA (<1 kb in length). In addition to the 5'-triphosphate moiety; blunt-end base pairing at the 5'-end of the RNA is very essential. Overhangs at the non-triphosphorylated end of the dsRNA RNA have no major impact on its activity. A 3'overhang at the 5'triphosphate end decreases and any 5'overhang at the 5' triphosphate end abolishes its activity. Upon ligand binding it associates with mitochondria antiviral signaling protein (MAVS/IPS1) which activates the IKK-related kinases: TBK1 and IKBKE which phosphorylate interferon regulatory factors: IRF3 and IRF7 which in turn activate transcription of antiviral immunological genes; including interferons (IFNs); IFN-alpha and IFN-beta. Detects both positive and negative strand RNA viruses including members of the families Paramyxoviridae: Human respiratory syncytial virus and measles virus (MeV); Rhabdoviridae: vesicular stomatitis virus (VSV); Orthomyxoviridae: influenza A and B virus; Flaviviridae: Japanese encephalitis virus (JEV); hepatitis C virus (HCV); dengue virus (DENV) and west Nile virus (WNV). It also detects rotavirus and reovirus. Also involved in antiviral signaling in response to viruses containing a dsDNA genome such as Epstein-Barr virus (EBV). Detects dsRNA produced from non-self dsDNA by RNA polymerase III; such as Epstein-Barr virus-encoded RNAs (EBERs). May play important roles in granulocyte production and differentiation; bacterial phagocytosis and in the regulation of cell migration.
- Gendetails:
- DExD/H-box helicase 58
- Host:
- Rabbit
- Immunogen:
- RIG-1 antibody was raised against human GST-tagged RIG-1 protein.
- Proteindetails:
- Probable ATP-dependent RNA helicase DDX58
- Aufreinigung:
- Ion Exchange
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- RIG-1 antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php