ASK1 Antibody
Produktgrößen
0.1 mg
£652,00
OAPB00376-0.1MG
Über dieses Produkt
- SKU:
- OAPB00376
- Zusätzliche Namen:
- apoptosis signal-regulating kinase 1;ASK1;ASK-1;MAP/ERK kinase kinase 5;MAPK/ERK kinase kinase 5;MAPKKK5;MEK kinase 5;MEKK 5;MEKK5;mitogen-activated protein kinase kinase kinase 5.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway. Plays an important role in the cascades of cellular responses evoked by changes in the environment. Mediates signaling for determination of cell fate such as differentiation and survival. Plays a crucial role in the apoptosis signal transduction pathway through mitochondria-dependent caspase activation. MAP3K5/ASK1 is required for the innate immune response; which is essential for host defense against a wide range of pathogens. Mediates signal transduction of various stressors like oxidative stress as well as by receptor-mediated inflammatory signals; such as the tumor necrosis factor (TNF) or lipopolysaccharide (LPS). Once activated; acts as an upstream activator of the MKK/JNK signal transduction cascade and the p38 MAPK signal transduction cascade through the phosphorylation and activation of several MAP kinase kinases like MAP2K4/SEK1; MAP2K3/MKK3; MAP2K6/MKK6 and MAP2K7/MKK7. These MAP2Ks in turn activate p38 MAPKs and c-jun N-terminal kinases (JNKs). Both p38 MAPK and JNKs control the transcription factors activator protein-1 (AP-1).
- Gendetails:
- mitogen-activated protein kinase kinase kinase 5
- Host:
- Rabbit
- Immunogen:
- ASK1 antibody was raised against a 16 amino acid synthetic peptide from near the carboxy terminus of human ASK1. The immunogen is located within amino acids 1260 - 1310 of ASK1.
- Proteindetails:
- Mitogen-activated protein kinase kinase kinase 5
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- ASK1 antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php