ERN1 Antibody
Produktgrößen
0.1 mg
£652,00
OAPB00366-0.1MG
Über dieses Produkt
- SKU:
- OAPB00366
- Zusätzliche Namen:
- Endoplasmic reticulum-to-nucleus signaling 1;ER to nucleus signalling 1;hIRE1p;inositol-requiring 1;inositol-requiring enzyme 1;inositol-requiring protein 1;IRE1;IRE1a;ire1-alpha;IRE1P;protein kinase/endoribonuclease;serine/threonine-protein kinase/endoribonuclease IRE1.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Serine/threonine-protein kinase and endoribonuclease that acts as a key sensor for the endoplasmic reticulum unfolded protein response (UPR) (PubMed:11779464; PubMed:11175748; PubMed:12637535; PubMed:9637683; PubMed:21317875). In unstressed cells; the endoplasmic reticulum luminal domain is maintained in its inactive monomeric state by binding to the endoplasmic reticulum chaperone HSPA5/BiP (PubMed:21317875). Accumulation of misfolded protein in the endoplasmic reticulum causes release of HSPA5/BiP; allowing the luminal domain to homodimerize; promoting autophosphorylation of the kinase domain and subsequent activation of the endoribonuclease activity (PubMed:21317875). The endoribonuclease activity is specific for XBP1 mRNA and excises 26 nucleotides from XBP1 mRNA (PubMed:11779464; PubMed:24508390; PubMed:21317875). The resulting spliced transcript of XBP1 encodes a transcriptional activator protein that up-regulates expression of UPR target genes (PubMed:11779464; PubMed:24508390; PubMed:21317875).
- Gendetails:
- endoplasmic reticulum to nucleus signaling 1
- Host:
- Rabbit
- Immunogen:
- IRE1p antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human IRE1p. The immunogen is located within amino acids 150 - 200 of IRE1p.
- Isotyp:
- IgG
- Proteindetails:
- Serine/threonine-protein kinase/endoribonuclease IRE1
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- IRE1p antibody can be stored at 4C for three months and -20C; stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze/thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php