ATG7 Antibody
Produktgrößen
0.1 mg
£652,00
OAPB00350-0.1MG
Über dieses Produkt
- SKU:
- OAPB00350
- Zusätzliche Namen:
- APG7 autophagy 7-like;APG7L;APG7-LIKE;ATG12-activating enzyme E1 ATG7;Autophagy-related protein 7;GSA7;hAGP7;SCAR31;ubiquitin-activating enzyme E1-like protein;ubiquitin-like modifier-activating enzyme ATG7.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress. Plays also a key role in the maintenance of axonal homeostasis; the prevention of axonal degeneration; the maintenance of hematopoietic stem cells; the formation of Paneth cell granules; as well as in adipose differentiation.
- Gendetails:
- autophagy related 7
- Host:
- Rabbit
- Immunogen:
- APG7 antibody was raised against a 17 amino acid synthetic peptide from near the amino terminus of human APG7. The immunogen is located within the first 50 amino acids of APG7.
- Molekulargewicht:
- Predicted: 77 kDa Observed: 77 kDa
- Proteindetails:
- Ubiquitin-like modifier-activating enzyme ATG7|ubiquitin-like modifier-activating enzyme ATG7 isoform a [Homo sapiens]
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- APG7 antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php