ACE2 Antibody
Produktgrößen
0.1 mg
£652,00
OAPB00220-0.1MG
Über dieses Produkt
- SKU:
- OAPB00220
- Zusätzliche Namen:
- ACEH;ACE-related carboxypeptidase;angiotensin I converting enzyme (peptidyl-dipeptidase A) 2;angiotensin I converting enzyme 2;angiotensin-converting enzyme 2;angiotensin-converting enzyme homolog;angiotensin-converting enzyme-related carboxypeptidase;metalloprotease MPROT15;peptidyl-dipeptidase A;truncated angiotensin converting enzyme 2.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Essential counter-regulatory carboxypeptidase of the renin-angiotensin hormone system that is a critical regulator of blood volume; systemic vascular resistance; and thus cardiovascular homeostasis (PubMed:27217402). Converts angiotensin I to angiotensin 1-9; a nine-amino acid peptide with anti-hypertrophic effects in cardiomyocytes; and angiotensin II to angiotensin 1-7; which then acts as a beneficial vasodilator and anti-proliferation agent; counterbalancing the actions of the vasoconstrictor angiotensin II (PubMed:10969042; PubMed:10924499; PubMed:11815627; PubMed:19021774; PubMed:14504186). Also removes the C-terminal residue from three other vasoactive peptides; neurotensin; kinetensin; and des-Arg bradykinin; but is not active on bradykinin (PubMed:10969042; PubMed:11815627). Also cleaves other biological peptides; such as apelins (apelin-13; [Pyr1]apelin-13; apelin-17; apelin-36); casomorphins (beta-casomorphin-7; neocasomorphin) and dynorphin A with high efficiency (PubMed:11815627; PubMed:27217402; PubMed:28293165). In addition; ACE2 C-terminus is homologous to collectrin and is responsible for the trafficking of the neutral amino acid transporter SL6A19 to the plasma membrane of gut epithelial cells via direct interaction; regulating its expression on the cell surface and its catalytic activity (PubMed:18424768; PubMed:19185582).
- Gendetails:
- angiotensin converting enzyme 2
- Host:
- Rabbit
- Immunogen:
- ACE2 antibody was raised against a synthetic peptide corresponding to amino acids near the center of human ACE2. The immunogen is located within amino acids 150 - 200 of ACE2.
- Isotyp:
- IgG
- Molekulargewicht:
- Predicted: 93kD Observed: 130 kD (7 N-linked glycosylation)
- Proteindetails:
- Angiotensin-converting enzyme 2|angiotensin-converting enzyme 2 precursor [Homo sapiens]
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Stored at 4°C for three months and -20°C; stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php