DEDAF Antibody
Produktgrößen
0.1 mg
£652,00
OAPB00091-0.1MG
Über dieses Produkt
- SKU:
- OAPB00091
- Zusätzliche Namen:
- AAP1;APAP-1;apoptin-associating protein 1;death effector domain-associated factor;DEDAF;DED-associated factor;RING1 and YY1-binding protein;ring1 interactor RYBP;YEAF1;YY1 and E4TF1 associated factor 1;YY1 and E4TF1-associated factor 1.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Component of a Polycomb group (PcG) multiprotein PRC1-like complex; a complex class required to maintain the transcriptionally repressive state of many genes; including Hox genes; throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119'; rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53; and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135; PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity).
- Gendetails:
- RING1 and YY1 binding protein
- Host:
- Rabbit
- Immunogen:
- DEDAF antibody was raised against a 14 amino acid peptide near the carboxy terminus of human DEDAF. The immunogen is located within the last 50 amino acids of DEDAF.
- Molekulargewicht:
- 32 kDa
- Proteindetails:
- Homo sapiens death effector domain-associated factor mRNA; complete cds|RING1 and YY1-binding protein
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php