ACIN1 Antibody
Produktgrößen
0.1 mg
£652,00
OAPB00086-0.1MG
Über dieses Produkt
- SKU:
- OAPB00086
- Zusätzliche Namen:
- ACINUS;ACN;apoptotic chromatin condensation inducer in the nucleus;fSAP152;functional spliceosome-associated protein 152.
- Klonalität:
- Polyclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1; but not cyclin A2; expression in leukemia cells.
- Gendetails:
- apoptotic chromatin condensation inducer 1
- Host:
- Rabbit
- Immunogen:
- Acinus antibody was raised against a peptide corresponding to amino acids near the carbosy terminus of human AcinusL; which are identical to those of mouse Acinus. The immunogen is located within the last 50 amino acids of Acinus.
- Molekulargewicht:
- 220 kDa
- Proteindetails:
- acinusL [Homo sapiens]|Apoptotic chromatin condensation inducer in the nucleus
- Aufreinigung:
- Affinity Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Acinus antibody can be stored at 4C; stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php