CAV1 Antibody
Produktgrößen
5µg
£186,00
OAPA00353-5UG
Über dieses Produkt
- SKU:
- OAPA00353
- Zusätzliche Namen:
- CGL3; PPH3; BSCL3; LCCNS; VIP21; MSTP085
- translate.label.attr.clone:
- PAT4C1AT
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The scaffolding protein encoded by the CAV1 gene is the key component of the caveolae plasma membranes found in most cell types. Cholesterol is vital for caveolae formation and maintenance; and caveolae structure is highly sensitive to cholesterol depletion or treatment with cholesterol binding drugs. CAV1 can tightly and specifically bind free cholesterol and artificial cholesterol containing vesicles. Caveolin 1 links integrin subunits to the tyrosine kinase FYN; which is an initiating step in coupling integrins to the Ras-ERK pathway and promoting cell cycle progression. CAV1 is a tumor suppressor gene candidate and a negative regulator of the Ras-p42/44 mitogen-activated kinase. Caveolin 1 and caveolin 2 are positioned next to each other on chromosome 7 and express co-localizing proteins which form a stable hetero-oligomeric complex cascade. Mutations in the CAV1 gene are linked to Berardinelli-Seip congenital lipodystrophy.
- Host:
- Mouse
- Immunogen:
- The immunogen for anti-CAV1 antibody: anti-human CAV1 mAb; is derived from hybridization of mouse FO myeloma cells with spleen cells from BALB/c mice immunized with recombinant human CAV1 amino acids 1-104 purified from E. coli.
- Isotyp:
- Mouse IgG2b heavy chain and kappa light chain.
- Proteindetails:
- Caveolin-1
- Reinheit:
- CAV1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
- Aufreinigung:
- CAV1 antibody was purified from mouse ascitic fluids by protein-G affinity chromatography.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For periods up to 1 month store at 4C; for periods up to 12 months; store at -20C. Prevent freeze thaw cycles. Please prevent freeze/thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php