Factor-IX Antibody
Produktgrößen
0.5mg
£485,00
OAPA00105-0.5MG
Über dieses Produkt
- SKU:
- OAPA00105
- Zusätzliche Namen:
- FIX; P19; PTC; HEMB; THPH8; F9 p22
- translate.label.attr.clone:
- NYRhFIX.
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml in PBS (after reconstitution)
- Weitere Details:
- Factor IX is a glycoprotein; which is synthesized in the liver. The domain structure of factor IX is similar to that of the other vitamin K dependent coagulation factors. The NH2-terminal region contains 12 g-carboxyglutamic acid (gla) residues; which facilitate the calcium dependent binding of factor IX to negatively charged phospholipid surfaces. Two domains which are homologous to epidermal growth factor (EGF) span the region between the NH2-terminal gla domain and the activation peptide (Ala-146 to Arg-180). Factor IX is activated by either factor XIa or the factor VIIa/tissue factor/phospholipid complex. Cleavage at site A yields the intermediate IXa; which is subsequently converted to the fully active form IXab by cleavage at site B. The NH2-terminal light chain (GLA and EGF domains) remains covalently attached to the COOH-terminal heavy chain by a disulfide bond. The serine protease catalytic triad (Ser-365; His 221; Asp-269) is located in the heavy chain. Factor IXab is the catalytic component of the "intrinsic factor Xase complex" (factor VIIIa/IXa/Ca2+/phospholipid) which proteolytically activates factor X to factor Xa.
- Host:
- Mouse
- Immunogen:
- The immunogen for anti-Factor-IX antibody: human Factor-IX.
- Isotyp:
- Mouse IgG.
- Proteindetails:
- Coagulation factor IX
- Aufreinigung:
- Protein A.
- Versandbedingungen:
- Ambient
- Lagerbedingungen:
- Reconstitute with H20 to get a 1 mg/ml concentration. Mix gently; wash the sides of the vial and wait 30-60 seconds before use. In lyophilized form; for long periods; store at 4C in a dry environment. After reconstitution; if not intended for use within a month; aliquot and store at -20C.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php