CDKN2A Antibody
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50 µg
£684,00
OALA04824-50UG
Über dieses Produkt
- SKU:
- OALA04824
- Zusätzliche Namen:
- ; INK4A; Multiple tumor suppressor 1; MTS-1; MTS1; p16-INK4A; p16 INK4A; p16INK4A; CDKN2A; cyclin-dependent kinase inhibitor 2A
- translate.label.attr.clone:
- 1E12E10
- Klonalität:
- Monoclonal
- Konjugat:
- Unconjugated
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes.
- Host:
- Mouse
- Immunogen:
- Full length recombinant p16INK4a NP_000068
- Isotyp:
- IgG1
- Aufreinigung:
- Affinity purified from ascites
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Short term: store at 4C. Long term: store at -20C. Avoid freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php