CHEK2 Antibody
Produktgrößen
100ul
£630,00
OAGA08717-100UL
Über dieses Produkt
- SKU:
- OAGA08717
- Zusätzliche Namen:
- CDS1; CHK2; LFS2; RAD53; hCds1; HuCds1; PP1425
- translate.label.attr.clone:
- 4B8
- Klonalität:
- Monoclonal
- Konzentration:
- 1.85 mg/ml
- Weitere Details:
- In response to DNA damage and replication blocks; cell cycle progression is halted through the control of critical cell cycle regulators. The protein encoded by this gene is a cell cycle checkpoint regulator and putative tumor suppressor. It contains a forkhead-associated protein interaction domain essential for activation in response to DNA damage and is rapidly phosphorylated in response to replication blocks and DNA damage. When activated; the encoded protein is known to inhibit CDC25C phosphatase; preventing entry into mitosis; and has been shown to stabilize the tumor suppressor protein p53; leading to cell cycle arrest in G1. In addition; this protein interacts with and phosphorylates BRCA1; allowing BRCA1 to restore survival after DNA damage. Mutations in this gene have been linked with Li-Fraumeni syndrome; a highly penetrant familial cancer phenotype usually associated with inherited mutations in TP53. Also; mutations in this gene are thought to confer a predisposition to sarcomas; breast cancer; and brain tumors. This nuclear protein is a member of the CDS1 subfamily of serine/threonine protein kinases. Several transcript variants encoding different isoforms have been found for this gene.
- Gendetails:
- checkpoint kinase 2
- Host:
- Mouse
- Isotyp:
- IgG1
- Proteindetails:
- serine/threonine-protein kinase Chk2
- Aufreinigung:
- Affinity purified by Protein G.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- For short term use; store at 4C. For extended use; aliquot and store at -20C. Avoid repeated freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php