DUT Antibody
Produktgrößen
100ul
£630,00
OAGA05686-100UL
Über dieses Produkt
- SKU:
- OAGA05686
- Zusätzliche Namen:
- dUTPase
- Klonalität:
- Polyclonal
- Konzentration:
- 0.49 mg/ml
- Weitere Details:
- This gene encodes an essential enzyme of nucleotide metabolism. The encoded protein forms a ubiquitous; homotetrameric enzyme that hydrolyzes dUTP to dUMP and pyrophosphate. This reaction serves two cellular purposes: providing a precursor (dUMP) for the synthesis of thymine nucleotides needed for DNA replication; and limiting intracellular pools of dUTP. Elevated levels of dUTP lead to increased incorporation of uracil into DNA; which induces extensive excision repair mediated by uracil glycosylase. This repair process; resulting in the removal and reincorporation of dUTP; is self-defeating and leads to DNA fragmentation and cell death. Alternative splicing of this gene leads to different isoforms that localize to either the mitochondrion or nucleus. A related pseudogene is located on chromosome 19.
- Gendetails:
- deoxyuridine triphosphatase
- Host:
- Rabbit
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human DUT. The exact sequence is proprietary.
- Isotyp:
- IgG
- Proteindetails:
- deoxyuridine 5'-triphosphate nucleotidohydrolase; mitochondrial
- Aufreinigung:
- Purified by antigen-affinity chromatography.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php