APPL2 Antibody - C-terminal region
Produktgrößen
100ul
£630,00
OAGA05371-100UL
Über dieses Produkt
- SKU:
- OAGA05371
- Zusätzliche Namen:
- DIP13B
- Klonalität:
- Polyclonal
- Konzentration:
- 0.3 mg/ml
- Weitere Details:
- The protein encoded by this gene is one of two effectors of the small GTPase RAB5A/Rab5; which are involved in a signal transduction pathway. Both effectors contain an N-terminal Bin/Amphiphysin/Rvs (BAR) domain; a central pleckstrin homology (PH) domain; and a C-terminal phosphotyrosine binding (PTB) domain; and they bind the Rab5 through the BAR domain. They are associated with endosomal membranes and can be translocated to the nucleus in response to the EGF stimulus. They interact with the NuRD/MeCP1 complex (nucleosome remodeling and deacetylase /methyl-CpG-binding protein 1 complex) and are required for efficient cell proliferation. A chromosomal aberration t(12;22)(q24.1;q13.3) involving this gene and the PSAP2 gene results in 22q13.3 deletion syndrome; also known as Phelan-McDermid syndrome.
- Gendetails:
- adaptor protein; phosphotyrosine interacting with PH domain and leucine zipper 2
- Host:
- Rabbit
- Immunogen:
- Recombinant protein encompassing a sequence within the C-terminus region of human DIP13B. The exact sequence is proprietary.
- Isotyp:
- IgG
- Proteindetails:
- DCC-interacting protein 13-beta
- Aufreinigung:
- Purified by antigen-affinity chromatography.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php