ERCC1 Antibody
Produktgrößen
100ul
£630,00
OAGA03612-100UL
Über dieses Produkt
- SKU:
- OAGA03612
- Zusätzliche Namen:
- UV20; COFS4; RAD10
- Klonalität:
- Polyclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- The product of this gene functions in the nucleotide excision repair pathway; and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4); and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome; and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule; epsilon associated protein gene on the opposite strand.
- Gendetails:
- ERCC excision repair 1; endonuclease non-catalytic subunit
- Host:
- Rabbit
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human ERCC1. The exact sequence is proprietary.
- Isotyp:
- IgG
- Proteindetails:
- DNA excision repair protein ERCC-1
- Aufreinigung:
- Purified by antigen-affinity chromatography.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php