DAG1 Antibody
Produktgrößen
100ul
£630,00
OAGA02461-100UL
Über dieses Produkt
- SKU:
- OAGA02461
- Zusätzliche Namen:
- A3a; DAG; AGRNR; 156DAG; MDDGA9; MDDGC7; MDDGC9; LGMDR16
- Klonalität:
- Polyclonal
- Konzentration:
- 0.66mg/ml
- Weitere Details:
- Dystroglycan is a laminin binding component of the dystrophin-glycoprotein complex which provides a linkage between the subsarcolemmal cytoskeleton and the extracellular matrix. Dystroglycan 1 is a candidate gene for the site of the mutation in autosomal recessive muscular dystrophies. The dramatic reduction of dystroglycan 1 in Duchenne muscular dystrophy leads to a loss of linkage between the sarcolemma and extracellular matrix; rendering muscle fibers more susceptible to necrosis. Dystroglycan also functions as dual receptor for agrin and laminin-2 in the Schwann cell membrane. The muscle and nonmuscle isoforms of dystroglycan differ by carbohydrate moieties but not protein sequence. Alternative splicing results in multiple transcript variants all encoding the same protein.
- Gendetails:
- dystroglycan 1 (dystrophin-associated glycoprotein 1)
- Host:
- Rabbit
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human alpha Dystroglycan. The exact sequence is proprietary.
- Isotyp:
- IgG
- Aufreinigung:
- Purified by antigen-affinity chromatography.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php