DDB1 Antibody
Produktgrößen
100ul
£630,00
OAGA01193-100UL
Über dieses Produkt
- SKU:
- OAGA01193
- Zusätzliche Namen:
- XPE; DDBA; XAP1; XPCE; XPE-BF; UV-DDB1
- Klonalität:
- Polyclonal
- Konzentration:
- 1mg/ml
- Weitere Details:
- The protein encoded by this gene is the large subunit (p127) of the heterodimeric DNA damage-binding (DDB) complex while another protein (p48) forms the small subunit. This protein complex functions in nucleotide-excision repair and binds to DNA following UV damage. Defective activity of this complex causes the repair defect in patients with xeroderma pigmentosum complementation group E (XPE) - an autosomal recessive disorder characterized by photosensitivity and early onset of carcinomas. However; it remains for mutation analysis to demonstrate whether the defect in XPE patients is in this gene or the gene encoding the small subunit. In addition; Best vitelliform mascular dystrophy is mapped to the same region as this gene on 11q; but no sequence alternations of this gene are demonstrated in Best disease patients. The protein encoded by this gene also functions as an adaptor molecule for the cullin 4 (CUL4) ubiquitin E3 ligase complex by facilitating the binding of substrates to this complex and the ubiquitination of proteins.
- Gendetails:
- damage-specific DNA binding protein 1; 127kDa
- Host:
- Rabbit
- Immunogen:
- Recombinant protein encompassing a sequence within the center region of human DDB1. The exact sequence is proprietary.
- Isotyp:
- IgG
- Aufreinigung:
- Purified by antigen-affinity chromatography.
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Keep as concentrated solution. Aliquot and store at -20C or below. Avoid multiple freeze-thaw cycles.
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Polyclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php