CD8A Antibody
Produktgrößen
0.1 mg (C100)
£272,00
OAEE00995-0.1MG
Über dieses Produkt
- SKU:
- OAEE00995
- Zusätzliche Namen:
- BB154331;Ly-;Ly-2;Ly-3;Ly-35;Ly-B;Lyt-;Lyt-2;Lyt-2.1 lymphocyte differentiation antigen (AA at 100);T-cell surface glycoprotein CD8 alpha chain;T-cell surface glycoprotein Lyt-2.
- translate.label.attr.clone:
- 53-6.7
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Konzentration:
- 0.5 mg/ml
- Weitere Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells; the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.
- Gendetails:
- CD8 antigen; alpha chain
- Host:
- Rat
- Immunogen:
- Murine spleen cells
- Isotyp:
- IgG2a
- Proteindetails:
- T-cell surface glycoprotein CD8 alpha chain
- Aufreinigung:
- Purified by size-exclusion chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php