CD40 Antibody
Produktgrößen
100 tests (T100)
£398,00
OAEE00853-100TESTS
Über dieses Produkt
- SKU:
- OAEE00853
- Zusätzliche Namen:
- B cell surface antigen CD40;B cell-associated molecule;Bp50;CD4 antigen;CD40 molecule; TNF receptor superfamily member 5;CD40L receptor;CDW40;p50;p55;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4;TNFRSF5;tumor necrosis factor receptor superfamily member 5;W3/25;W3/25 antigen.
- translate.label.attr.clone:
- HI40a
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Konzentration:
- 20 ul / test
- Weitere Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells; plays a role in differentiation/activation; cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
- Gendetails:
- Cd4 molecule|CD40 molecule
- Host:
- Mouse
- Immunogen:
- Human CD40a
- Isotyp:
- IgG1
- Proteindetails:
- T-cell surface glycoprotein CD4
- Aufreinigung:
- Purified by size-exclusion chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php