CD177 Antibody
Produktgrößen
100 tests (T100)
£398,00
OAEE00679-100TESTS
Über dieses Produkt
- SKU:
- OAEE00679
- Zusätzliche Namen:
- CD177 antigen;cell surface receptor;HNA-2a;HNA2A;human neutrophil alloantigen 2a;NB1;NB1 glycoprotein;NB1 GP;polycythemia rubra vera protein 1;PRV1;PRV-1.
- translate.label.attr.clone:
- MEM-166
- Klonalität:
- Monoclonal
- Konjugat:
- FITC
- Konzentration:
- 20 ul / test
- Weitere Details:
- In association with beta-2 integrin heterodimer ITGAM/CD11b and ITGB2/CD18; mediates activation of TNF-alpha primed neutrophils including degranulation and superoxide production (PubMed:21193407). In addition; by preventing beta-2 integrin internalization and attenuating chemokine signaling favors adhesion over migration (PubMed:28807980). Heterophilic interaction with PECAM1 on endothelial cells plays a role in neutrophil transendothelial migration in vitro (PubMed:17580308). However; appears to be dispensable for neutrophil recruitment caused by bacterial infection in vivo (PubMed:23461681). Acts as a receptor for the mature form of protease PRTN3 allowing its display at the cell surface of neutrophils (PubMed:17244676; PubMed:18462208). By displaying PRTN3 at the neutrophil cell surface; may play a role in enhancing endothelial cell junctional integrity and thus vascular integrity during neutrophil diapedesis (PubMed:23202369).
- Gendetails:
- CD177 molecule
- Host:
- Mouse
- Immunogen:
- Human granulocytes
- Isotyp:
- IgG1
- Proteindetails:
- CD177 antigen
- Aufreinigung:
- Purified by size-exclusion chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php