CD163 Antibody
Produktgrößen
100 tests (T100)
£441,00
OAEE00677-100TESTS
Über dieses Produkt
- SKU:
- OAEE00677
- Zusätzliche Namen:
- hemoglobin scavenger receptor;M130;macrophage-associated antigen;MM130;SCARI1;scavenger receptor cysteine-rich type 1 protein M130.
- translate.label.attr.clone:
- GHI/61
- Klonalität:
- Monoclonal
- Konjugat:
- R-PE
- Konzentration:
- 10 ul / test
- Weitere Details:
- Acute phase-regulated receptor involved in clearance and endocytosis of hemoglobin/haptoglobin complexes by macrophages and may thereby protect tissues from free hemoglobin-mediated oxidative damage. May play a role in the uptake and recycling of iron; via endocytosis of hemoglobin/haptoglobin and subsequent breakdown of heme. Binds hemoglobin/haptoglobin complexes in a calcium-dependent and pH-dependent manner. Exhibits a higher affinity for complexes of hemoglobin and multimeric haptoglobin of HP*1F phenotype than for complexes of hemoglobin and dimeric haptoglobin of HP*1S phenotype. Induces a cascade of intracellular signals that involves tyrosine kinase-dependent calcium mobilization; inositol triphosphate production and secretion of IL6 and CSF1. Isoform 3 exhibits the higher capacity for ligand endocytosis and the more pronounced surface expression when expressed in cells.
- Gendetails:
- CD163 molecule
- Host:
- Mouse
- Immunogen:
- Hairy cell leukemia cells
- Isotyp:
- IgG1
- Proteindetails:
- Scavenger receptor cysteine-rich type 1 protein M130
- Aufreinigung:
- Purified by size-exclusion chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php