CDKN1A Antibody
Produktgrößen
0.1 mg (C100)
£337,00
OAEE00510-0.1MG
Über dieses Produkt
- SKU:
- OAEE00510
- Zusätzliche Namen:
- CAP20;CDK-interacting protein 1;CDK-interaction protein 1;CDKN1;CIP1;cyclin-dependent kinase inhibitor 1;cyclin-dependent kinase inhibitor 1A (p21; Cip1);DNA synthesis inhibitor;MDA-6;melanoma differentiation associated protein 6;Melanoma differentiation-associated protein 6;P21;p21CIP1;SDI1;WAF1;wild-type p53-activated fragment 1.
- translate.label.attr.clone:
- WA-1
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- May be involved in p53/TP53 mediated inhibition of cellular proliferation in response to DNA damage. Binds to and inhibits cyclin-dependent kinase activity; preventing phosphorylation of critical cyclin-dependent kinase substrates and blocking cell cycle progression. Functions in the nuclear localization and assembly of cyclin D-CDK4 complex and promotes its kinase activity towards RB1. At higher stoichiometric ratios; inhibits the kinase activity of the cyclin D-CDK4 complex. Inhibits DNA synthesis by DNA polymerase delta by competing with POLD3 for PCNA binding (PubMed:11595739).
- Gendetails:
- cyclin dependent kinase inhibitor 1A
- Host:
- Mouse
- Immunogen:
- Human p21 protein
- Isotyp:
- IgG1
- Proteindetails:
- Cyclin-dependent kinase inhibitor 1
- Reinheit:
- > 95% (by SDS-PAGE)
- Aufreinigung:
- Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php