FOXP3 Antibody
Produktgrößen
0.1 mg (C100)
£441,00
OAEE00392-0.1MG
Über dieses Produkt
- SKU:
- OAEE00392
- Zusätzliche Namen:
- AIID;DIETER;forkhead box protein P3;FOXP3delta7;immune dysregulation; polyendocrinopathy; enteropathy; X-linked;immunodeficiency; polyendocrinopathy; enteropathy; X-linked;IPEX;JM2;PIDX;Scurfin;XPID.
- translate.label.attr.clone:
- 3G3
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells (Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage; and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors; histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes; including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2 (IL2) and interferon-gamma (IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors; RELA and NFATC2 (PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7 (PubMed:17360565). Can activate the expression of TNFRSF18; IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1 (PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells (Th17) by antagonizing RORC function; leading to down-regulation of IL17 expression; favoring Treg development (PubMed:18368049). Inhibits the transcriptional activator activity of RORA (PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4 (By similarity).
- Gendetails:
- forkhead box P3
- Host:
- Mouse
- Immunogen:
- Full-length His-tagged recombinant murine FoxP3
- Isotyp:
- IgG1
- Proteindetails:
- Forkhead box protein P3
- Reinheit:
- > 95% (by SDS-PAGE)
- Aufreinigung:
- Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php