CSK Antibody
Produktgrößen
0.1 ml (R100)
£398,00
OAEE00364-0.1ML
Über dieses Produkt
- SKU:
- OAEE00364
- Zusätzliche Namen:
- CSK; non-receptor tyrosine kinase;C-Src kinase;c-src tyrosine kinase;protein-tyrosine kinase CYL;tyrosine-protein kinase CSK.
- translate.label.attr.clone:
- CSK-04
- Klonalität:
- Monoclonal
- Weitere Details:
- Non-receptor tyrosine-protein kinase that plays an important role in the regulation of cell growth; differentiation; migration and immune response. Phosphorylates tyrosine residues located in the C-terminal tails of Src-family kinases (SFKs) including LCK; SRC; HCK; FYN; LYN or YES1. Upon tail phosphorylation; Src-family members engage in intramolecular interactions between the phosphotyrosine tail and the SH2 domain that result in an inactive conformation. To inhibit SFKs; CSK is recruited to the plasma membrane via binding to transmembrane proteins or adapter proteins located near the plasma membrane. Suppresses signaling by various surface receptors; including T-cell receptor (TCR) and B-cell receptor (BCR) by phosphorylating and maintaining inactive several positive effectors such as FYN or LCK.
- Gendetails:
- C-terminal Src kinase
- Host:
- Mouse
- Immunogen:
- Bacterially expressed recombinant fragment of human Csk corresponding to aa 330-450.
- Isotyp:
- IgG1
- Proteindetails:
- Tyrosine-protein kinase CSK
- Reinheit:
- > 95% (by SDS-PAGE)
- Aufreinigung:
- Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php