CD84 Antibody
Produktgrößen
0.1 mg (C100)
£326,00
OAEE00323-0.1MG
Über dieses Produkt
- SKU:
- OAEE00323
- Zusätzliche Namen:
- CD84 antigen (leukocyte antigen);cell surface antigen MAX.3;hCD84;hly9-beta;leucocyte differentiation antigen CD84;leukocyte antigen CD84;leukocyte differentiation antigen CD84;LY9B;mCD84;signaling lymphocytic activation molecule 5;SLAM family member 5;SLAMF5.
- translate.label.attr.clone:
- CD84.1.21
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Self-ligand receptor of the signaling lymphocytic activation molecule (SLAM) family. SLAM receptors triggered by homo- or heterotypic cell-cell interactions are modulating the activation and differentiation of a wide variety of immune cells and thus are involved in the regulation and interconnection of both innate and adaptive immune response. Activities are controlled by presence or absence of small cytoplasmic adapter proteins; SH2D1A/SAP and/or SH2D1B/EAT-2. Can mediate natural killer (NK) cell cytotoxicity dependent on SH2D1A and SH2D1B (By similarity). Increases proliferative responses of activated T-cells and SH2D1A/SAP does not seem be required for this process. Homophilic interactions enhance interferon gamma/IFNG secretion in lymphocytes and induce platelet stimulation via a SH2D1A-dependent pathway. May serve as a marker for hematopoietic progenitor cells (PubMed:11564780; PubMed:12115647. PubMed:12928397; PubMed:12962726; PubMed:16037392) Required for a prolonged T-cell:B-cell contact; optimal T follicular helper function; and germinal center formation. In germinal centers involved in maintaining B-cell tolerance and in preventing autoimmunity (By similarity). In mast cells negatively regulates high affinity immunoglobulin epsilon receptor signaling; independent of SH2D1A and SH2D1B but implicating FES and PTPN6/SHP-1 (PubMed:22068234). In macrophages enhances LPS-induced MAPK phosphorylation and NF-kappaB activation and modulates LPS-induced cytokine secretion; involving ITSM 2 (By similarity).
- Gendetails:
- CD84 molecule
- Host:
- Mouse
- Immunogen:
- CD84-transfected 300.19 cell line
- Isotyp:
- IgG2a
- Proteindetails:
- SLAM family member 5
- Reinheit:
- > 95% (by SDS-PAGE)
- Aufreinigung:
- Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php