CD4 Antibody
Produktgrößen
0.1 mg (C100)
£398,00
OAEE00227-0.1MG
Über dieses Produkt
- SKU:
- OAEE00227
- Zusätzliche Namen:
- CD4 antigen (p55);CD4 receptor;CD4mut;IMD79;OKT4D;T-cell surface antigen T4/Leu-3;T-cell surface glycoprotein CD4.
- translate.label.attr.clone:
- MEM-241
- Klonalität:
- Monoclonal
- Konjugat:
- Biotin
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells; functions primarily as a coreceptor for MHC class II molecule:peptide complex. The antigens presented by class II peptides are derived from extracellular proteins while class I peptides are derived from cytosolic proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class II presented by antigen presenting cells (APCs). In turn; recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production; motility; adhesion and activation of T-helper cells. In other cells such as macrophages or NK cells; plays a role in differentiation/activation; cytokine expression and cell migration in a TCR/LCK-independent pathway. Participates in the development of T-helper cells in the thymus and triggers the differentiation of monocytes into functional mature macrophages.
- Gendetails:
- CD4 molecule
- Host:
- Mouse
- Immunogen:
- 2 N-terminal domains of human CD4 fused to human IgG1 Fc
- Isotyp:
- IgG1
- Proteindetails:
- T-cell surface glycoprotein CD4
- Aufreinigung:
- Purified by size-exclusion chromatography
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php