Cd3e Antibody
Produktgrößen
0.1 mg (C100)
£326,00
OAEE00185-0.1MG
Über dieses Produkt
- SKU:
- OAEE00185
- Zusätzliche Namen:
- CD3e antigen; epsilon polypeptide (TiT3 complex);CD3e molecule; epsilon (CD3-TCR complex);CD3-epsilon;IMD18;T3E;T-cell antigen receptor complex; epsilon subunit of T3;T-cell surface antigen T3/Leu-4 epsilon chain;T-cell surface glycoprotein CD3 epsilon chain;TCRE.
- translate.label.attr.clone:
- OKT3
- Klonalität:
- Monoclonal
- Konzentration:
- 1 mg/ml
- Weitere Details:
- Part of the TCR-CD3 complex present on T-lymphocyte cell surface that plays an essential role in adaptive immune response. When antigen presenting cells (APCs) activate T-cell receptor (TCR); TCR-mediated signals are transmitted across the cell membrane by the CD3 chains CD3D; CD3E; CD3G and CD3Z. All CD3 chains contain immunoreceptor tyrosine-based activation motifs (ITAMs) in their cytoplasmic domain. Upon TCR engagement; these motifs become phosphorylated by Src family protein tyrosine kinases LCK and FYN; resulting in the activation of downstream signaling pathways (PubMed:2470098). In addition of this role of signal transduction in T-cell activation; CD3E plays an essential role in correct T-cell developement. Initiates the TCR-CD3 complex assembly by forming the two heterodimers CD3D/CD3E and CD3G/CD3E. Participates also in internalization and cell surface down-regulation of TCR-CD3 complexes via endocytosis sequences present in CD3E cytosolic region (PubMed:10384095; PubMed:26507128).
- Gendetails:
- CD3e molecule
- Host:
- Mouse
- Immunogen:
- human T cells
- Isotyp:
- IgG2a
- Proteindetails:
- T-cell surface glycoprotein CD3 epsilon chain
- Reinheit:
- > 95% (by SDS-PAGE)
- Aufreinigung:
- Purified
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- 2Â[o]C to 8Â[o]C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php