Anti-RANKL
Produktgrößen
100 ug
£652,00
OAED00365-100UG
Über dieses Produkt
- SKU:
- OAED00365
- Zusätzliche Namen:
- CD254;hRANKL2;ODF;OPGL;OPTB2;osteoclast differentiation factor;osteoprotegerin ligand;RANKL;receptor activator of nuclear factor kappa B ligand;Receptor activator of nuclear factor kappa-B ligand;sOdf;TNF-related activation-induced cytokine;TNLG6B;TRANCE;tumor necrosis factor (ligand) superfamily; member 11;tumor necrosis factor ligand 6B;tumor necrosis factor ligand superfamily member 11;tumor necrosis factor superfamily member 11.
- translate.label.attr.clone:
- Ranky-1
- Klonalität:
- Monoclonal
- Konzentration:
- 1mg/ml
- Weitere Details:
- Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells; chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1; which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation; in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation (By similarity).
- Gendetails:
- TNF superfamily member 11
- Host:
- Rat
- Immunogen:
- Recombinant human soluble RANKL extracellular domain (aa 151-316) (Prod. No. ALX-522-012).
- Isotyp:
- IgG1
- Proteindetails:
- Tumor necrosis factor ligand superfamily member 11
- Reinheit:
- ≥95% (SDS-PAGE)
- Versandbedingungen:
- Blue Ice
- Quelle:
- Purified from concentrated hybridoma tissue culture supernatant.
- Lagerbedingungen:
- Long Term Storage : -20C
Short Term Storage : +4C
Handling : Avoid freeze/thaw cycles.
Stable for at least 1 year after receipt when stored at -20C. - Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php