Anti-RIP2
Produktgrößen
100 ug
£669,00
OAED00310-100UG
Über dieses Produkt
- SKU:
- OAED00310
- Zusätzliche Namen:
- CARD3;CARD-carrying kinase;CARD-containing IL-1 beta ICE-kinase;CARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinase;CARD-containing interleukin-1 beta-converting enzyme-associated kinase;CARDIAK;CCK;GIG30;growth-inhibiting gene 30;receptor-interacting protein (RIP)-like interacting caspase-like apoptosis regulatory protein (CLARP) kinase;receptor-interacting protein 2;receptor-interacting serine/threonine-protein kinase 2;RICK;RIP2;RIP-2;RIP-like-interacting CLARP kinase;tyrosine-protein kinase RIPK2.
- translate.label.attr.clone:
- Nick-1
- Klonalität:
- Monoclonal
- Konzentration:
- 1mg/ml
- Weitere Details:
- Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans; NOD1 and NOD2 are activated; oligomerize and recruit RIPK2 through CARD-CARD domains. Contributes to the tyrosine phosphorylation of the guanine exchange factor ARHGEF2 through Src tyrosine kinase leading to NF-kappaB activation by NOD2. Once recruited; RIPK2 autophosphorylates and undergoes 'Lys-63'-linked polyubiquitination by E3 ubiquitin ligases XIAP; BIRC2 and BIRC3. The polyubiquitinated protein mediates the recruitment of MAP3K7/TAK1 to IKBKG/NEMO and induces 'Lys-63'-linked polyubiquitination of IKBKG/NEMO and subsequent activation of IKBKB/IKKB. In turn; NF-kappa-B is released from NF-kappa-B inhibitors and translocates into the nucleus where it activates the transcription of hundreds of genes involved in immune response; growth control; or protection against apoptosis. Plays also a role during engagement of the T-cell receptor (TCR) in promoting BCL10 phosphorylation and subsequent NF-kappa-B activation.
- Gendetails:
- receptor interacting serine/threonine kinase 2
- Host:
- Rat
- Immunogen:
- Recombinant human RIP2 (receptor-interacting protein 2) (aa 1-322).
- Isotyp:
- IgG2a
- Proteindetails:
- Receptor-interacting serine/threonine-protein kinase 2
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Long Term Storage : -20C
Short Term Storage : +4C
Handling :
Stable for at least 1 year after receipt when stored as recommended. - Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php