Anti-HSF1
Produktgrößen
50 ug
£398,00
OAED00212-50UG
Über dieses Produkt
- SKU:
- OAED00212
- Zusätzliche Namen:
- AA960185;heat shock factor protein 1;Heat shock transcription factor 1;Hsf1alpha;Hsf1beta;HSTF;HSTF 1.
- translate.label.attr.clone:
- 10H8
- Klonalität:
- Monoclonal
- Weitere Details:
- Function as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR); leading to the expression of a large class of molecular chaperones heat shock proteins (HSPs) that protect cells from cellular insults' damage. In unstressed cells; is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form. Upon exposure to heat and other stress stimuli; undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes. Activation is reversible; and during the attenuation and recovery phase period of the HSR; returns to its unactivated form. Binds to inverted 5'-NGAAN-3' pentamer DNA sequences. Binds to chromatin at heat shock gene promoters. Plays also several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells. Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner. Plays a role in nuclear export of stress-induced HSP70 mRNA. Plays a role in the regulation of mitotic progression. Plays also a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner. Involved in stress-induced cancer cell proliferation in a IER5-dependent manner.
- Gendetails:
- heat shock factor 1
- Host:
- Rat
- Immunogen:
- Recombinant mouse HSF1.
- Isotyp:
- IgG1
- Proteindetails:
- Heat shock factor protein 1
- Reinheit:
- Protein G affinity purified.<br/>
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Long Term Storage : -20C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php