Anti-Stat3
Produktgrößen
100 ug
£571,00
OAED00024-100UG
Über dieses Produkt
- SKU:
- OAED00024
- Zusätzliche Namen:
- acute-phase response factor;ADMIO;ADMIO1;APRF;DNA-binding protein APRF;HIES;signal transducer and activator of transcription 3.
- translate.label.attr.clone:
- 7G8
- Klonalität:
- Monoclonal
- Weitere Details:
- Signal transducer and transcription activator that mediates cellular responses to interleukins; KITLG/SCF; LEP and other growth factors (PubMed:10688651; PubMed:12359225; PubMed:12873986; PubMed:15194700; PubMed:17344214; PubMed:18242580; PubMed:23084476). Once activated; recruits coactivators; such as NCOA1 or MED1; to the promoter region of the target gene (PubMed:17344214). May mediate cellular responses to activated FGFR1; FGFR2; FGFR3 and FGFR4 (PubMed:12873986). Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes (PubMed:12359225). Activated by IL31 through IL31RA (PubMed:15194700). Acts as a regulator of inflammatory response by regulating differentiation of naive CD4(+) T-cells into T-helper Th17 or regulatory T-cells (Treg): deacetylation and oxidation of lysine residues by LOXL3; leads to disrupt STAT3 dimerization and inhibit its transcription activity (PubMed:28065600). Involved in cell cycle regulation by inducing the expression of key genes for the progression from G1 to S phase; such as CCND1 (PubMed:17344214). Mediates the effects of LEP on melanocortin production; body energy homeostasis and lactation (By similarity). May play an apoptotic role by transctivating BIRC5 expression under LEP activation (PubMed:18242580). Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity (PubMed:23084476). Plays a crucial role in basal beta cell functions; such as regulation of insulin secretion (By similarity).
- Gendetails:
- signal transducer and activator of transcription 3
- Host:
- Mouse
- Immunogen:
- Recombinant full length human Stat3.
- Proteindetails:
- Signal transducer and activator of transcription 3
- Reinheit:
- Protein A affinity purified.<br/>
- Versandbedingungen:
- Blue Ice
- Lagerbedingungen:
- Long Term Storage : -20C
- Hersteller:
- Aviva Systems Biology
- Typ:
- Antibodies: Monoclonal Antibody
- Datenblatt des Herstellers:html_datasheet.php